The trial was conducted in more than 16,000 Thailand volunteers. The HVTN 505 trial, which started recruiting participants about a month ago and has enrolled about 30 people thus far, is what Hammer called an "advanced Phase II" trial that will seek to investigate the effects of an HIV vaccine on modulating the viral load in any of the 1350 participants who end up contracting the virus. Like the Thai trial, the HVTN 505 trial uses the "prime-boost" regimen -- where a first round of injections readies the immune system to recognize and combat HIV and a second ramps up immune activity -- but uses a different vector and different vaccine contents.
The vaccine regimen tested in Thailand consisted of priming shots of a canarypox vector carrying three synthetic HIV genes and booster shots of a recombinant form of gp120, a surface protein found in HIV clades B and E. The HVTN 505 study, which is being co-sponsored by the National Institute of Allergy and Infectious Diseases, will administer three priming shots of a recombinant DNA-based vaccine with three HIV genes from clade B followed by booster shots containing the adenovirus serotype 5 (Ad5) vector with HIV viral envelope genes from clades A, B and C.
A principal investigator of the only other ongoing efficacy trial of an HIV vaccine, however, said that "the project needs to be examined more closely to analyze data on subgroup analyses and specific immune responses so that subsequent trials can absorb that information".
The vice president for vaccine development at the International AIDS Vaccine Initiative, added that the Thai trial is providing promising initial data, 30% efficacy is on the low end of the spectrum regarding the vaccine's potential licensure, explained Hassell. Vaccines typically achieve efficacies of 60-90% before they are officially licensed by the US Food and Drug Administration, he said. This means that the results will spur further research, but the world will have to wait longer for a safe and effective HIV vaccine.
thanks for the information, dan fulani, please keep us posted
even though there is a considerable amount of awareness on
hiv/aids among our people than before, which results indicates
considerable drop in infection.
yes, we need to be patient.
Yeh!!! only that I am not a fulani, Iam a Hausa man, na Tanko mai kan bashi, Tabarya kowa ya hadiye ki ya kwan tsaye. Ka gane, Mallam Babarbare? Yaya Kano tare da mutanen cikin ta? Yaya Nigeria? Ina wa kowa da kowa barka da sallah!!! Alhamdu Lillah, a bane dai an tashi da azumi rana daya duk duniya, kuma anyi karamar sallah rana daya!!!
sannunki da shan ruwa kuma barkda da sallah
mun yi samani cewa ke fulata ne ashe ke afuno
ne? yayi kyau, Allah ya bamu wani sabon sallah
amin.
Assalamu alaikum Malamin Magulmari,
Wayyo, ina ma kasan labarin da Mallam Bambadiya da wata rana ya gaya wa dalibansa game da mutanen dake Kanem!!! Idan baka sani ba, to ina fatan zaka tambayi duk wani bazazzagen da ka sani, zai gaya maka, domin ba'a bar Zazzagawa a baya ba gurin harshen Hausa!!!
Do Allah ka gaya min, domin ban sani ba, yaya ake kiran mace a Borno? Kai? ko kuma yaya? Nayi wan nan tambayar ne sabo da ina fatan zuwa Maiduguri, Insha Allah, ina dawo wa gida Nigeria, akwai wurin wata babarbariya da nake so inje, kuma ina so in sani yaya zan gabatar da kaina!!!
Alanguburo, Allah Ya kara maka girman yawani!!!!!!!!!!!!
Wassalamu alaikum.